| Date |
Away |
Time |
Home |
| 23 Jan 2022 | Round 16 |
 Burkina Faso |
1-1 Limbe Omnisport Stadium,Limbe
|
 Gabon |
| 23 Jan 2022 |Round 16 |
 Nigeria |
0-1 Stade Roumdé Adjia,Garoua
|
 Tunisia |
| 24 Jan 2022 | Round 16 |
 Guinea |
0-1 Stade de Kouekong,Bafoussam
|
 Gambia |
| 24 Jan 2022 |Round 16 |
 Cameroon |
2-1 Stade d'Olembé,Yaoundé
|
 Comoros |
| 25 Jan 2022 | Round 16 |
 Senegal |
2-0 Stade de Japoma,Douala
|
 Cape Verde |
| 25 Jan 2022 |Round 16 |
 Morocco |
2-1 Stade Ahmadou Ahidjo,Yaoundé
|
Malawi |
| 26 Jan 2022 | Round 16 |
 Ivory Coast |
0-0 Stade de Japoma,Douala
|
 Egypt |
| 26 Jan 2022 |Round 16 |
 Mali |
0-0 Limbe Omnisport Stadium,Limb
|
 Equatorial Guinea |